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生醫科技

分割多磷酸EX-polyP®

刊登於國際期刊的論文和發表的文章

柴肇一博士(T. Shiba) 在北海道大學組成他的研發團隊，30年來共發表多磷酸的論文高達39篇以上， 其中與 Arthur Kornberg 共同署名的有三篇以上。將其運用於解決有關牙周病的問題，取得了成功和豐碩的成果。

Articles

  1. WD Lee, R. Gawri, T. Shiba, WL. Stanford, RA. Kandel, Simple silica column-based method to quantify inorganic polyphosphates in cartilage and other tissues. Cartilage, March 16, (2017)
  2. T. Shiba, Inorganic polyphosphate and its chain length dependency in periodontal tissue regeneration including bone remodeling and teeth whitening., in Chapter 10 of Inorganic Polyphosphates in Eukaryotic Cells., T. Kulakovskaya, E. Pavlov, EN. Dedkova Eds. (2016).
  3. LC. Wijeyewickrema, E. Lameignere, RC. Duncan, T. Shiba, RJ. Travers, PR. Kapopara, VL. Stephanie, H. Kim, JH. Morrissey, RN. Pike, EM. Conway, Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor. Blood, 128, 1766-1776 (2016).
  4. PR. Angelova, BK. Agrawalla, PA. Elustondo, J. Gordon, T. Shiba, AY. Abramov, YT. Chang, EV. Pavlov, In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8., ACS Chem. Biol., 9, 2101-2110 (2014).
  5. K. Doi, T. Kubo, R. Takeshita, S. Kajihara, S. Kato, Y. Kawazoe, T. Shiba, Y. Akagawa, Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study., Dent. Mater. J., 33, 179-186 (2014).
  6. WD. Lee, R. Gawri, T. Shiba, AR. Ji, WL. Stanford, RA. Kandel, Simple silica column-based method to quantify inorganic polyphosphates in cartilage and other tissues., Cartilage, Mar. 1 (2017).
  7. H. Ogawa, C. Kurokawa, M. Hoshino, K. Tamaoka, T. Toko, T. Shiba, A. Manabe, Bleaching agent containing polyphosphate –Influence on bleaching effect, accumulation of stain, and prevention of decalcification-., Jpn. J Conserv. Dent., 59, 197-205 (2016).
  8. T. Shiba, Inorganic polyphosphate and its chain length dependency in periodontal tissue regeneration including bone remodeling and teeth whitening., in Chapter 10 of Inorganic Polyphosphates in Eukaryotic Cells., T. Kulakovskaya, E. Pavlov, EN. Dedkova Eds. (2016).
  9. LC. Wijeyewickrema, E. Lameignere, RC. Duncan, T. Shiba, RJ. Travers, PR. Kapopara, VL. Stephanie, H. Kim, JH. Morrissey, RN. Pike, EM. Conway, Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor., Blood, 128, 1766-1776 (2016).
  10. PR. Angelova, BK. Agrawalla, PA. Elustondo, J. Gordon, T. Shiba, AY. Abramov, YT. Chang, EV. Pavlov, In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8., ACS Chem. Biol., 9, 2101-2110 (2014).
  11. K. Doi, T. Kubo, R. Takeshita, S. Kajihara, S. Kato, Y. Kawazoe, T. Shiba, Y. Akagawa, Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study., Dent. Mater. J., 33, 179-186 (2014).
  12. M. Koyasu, T. Shiba, Y. Kawazoe, A, Manabe, T. Miyazaki, Ultraphosphate, a potent stain control agent that is effective for both stain removal and prevention of stain deposition., Dent. Mater. J., 33, 1-9 (2014).
  13. K. Tsutsumi, N. Saito, Y. Kawazoe, H-K. Ooi, T. Shiba, Morphogenetic study on the maturation of osteoblastic cell as induced by inorganic polyphosphate., PLOS ONE, 9, issue 2, e86834 (2014).
  14. K. Harada, H. Itoh, Y. Kawazoe, S. Miyazaki, K. Doi, T. Kubo, Y. Akagawa, T. Shiba, Polyphosphate-mediated inhibition of tartrate-resistant acid phosphatase and suppression of bone resorption of osteoclasts., PLOS ONE, 8, issue 11, e78612 (2013).
  15. K. Harada, T. Shiba, K. Doi, K. Morita, T. Kubo, Y. Makihara, A. Piattelli, Y. Akagawa, Inorganic polyphosphate suppreses lipopolysaccharide-induced inducible nitric oxide synthase (iNOS) expression in macrophages., PLOS ONE, 8, issue 9, e74650 (2013).
  16. N. Sun, H. Zou, L. Yang, K. Morita, P. Gong, T. Shiba, Y. Akagawa, Q. Yuan, Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway., Biochem. Biophys. Res. Com., 428, 298-302 (2012).
  17. D. Morimoto, T. Tomita, S. Kuroda, C. Higuchi, S. Kato, T. Shiba, H. Nakagami, R. Morishita, H. Yoshikawa, Inorganic polyphosphate differentiates human mesenchymal stem cells into osteoblastic cells., J. Bone Miner. Metab., 28, 418-423 (2010).
  18. M. Yamaoka, M. Ishizuka, K. Ishihama, M. Takahashi, M. Takahashi, H. Yamada, Y. Teramoto, K. Yasuda, T. Shiba, T. Uematsu, K. Furusawa, Bone formation without lamina dura in the middle-aged and elderly: possible dependence on enamel., Clinical Interventions in Aging, 5, 37-43 (2010).
  19. K. Morita, K. Doi, T. Kubo, R. Takeshita, S. Kato, T. Shiba, Y. Akgagawa, Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite., Acta Biomaterialia, 6, 2808-2815 (2010).
  20. Q. Yuan, T. Kubo, K. Doi, K. Morita, R. Takeshita, S. Katoh, T. Shiba, P. Gong, Y. Akagawa, Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration., Acta Biomaterialia, 5, 1716-1724 (2009).
  21. Y. Kawazoe, S. Katoh, Y. Onodera, T. Kohgo, M. Shindoh, T. Shiba, Activation of the FGF signaling pathway and subsequent induction of mesenchymal stem cell differentiation by inorganic polyphosphate., Int. J. Biol. Sci., 4, 37-47 (2008).
  22. M. Yamaoka, T. Uematsu, T. Shiba, T. Matsuura, Y. Ono, M. Ishizuka, H. Naramoto, M. Takahashi, M. Sugiura-Tomita, K. Iguchi, S. Yamashita, K. Furusawa, Effect of inorganic polyphosphate in periodontitis in the elderly., Gerodontology., 25, 10-17 (2008).
  23. Y. Hacchou, T. Uematsu, O. Ueda, Y. Usui, S. Uematsu, M. Takahashi, T. Uchihashi, Y. Kawazoe, T. Shiba, S. Kurihara, M. Yamaoka, K. Furusawa., Inorganic polyphosphate: a possible stimulant of bone formation., J. Dent. Res., 86, 893-897 (2007).
  24. P. McInerney, T. Mizutani, T. Shiba, Inorganic polyphosphate interacts with ribosomes and promotes translation fidelity in vitro and in vivo. Mol. Microbiol. 60, 438-447 (2006).
  25. H. Itoh, Y. Kawazoe, T. Shiba, Enhancement of protein synthesis by an inorganic polyphosphate in an E. coli cell-free system., J. Microbiol. Methods. 64, 241-249 (2006).
  26. H. Zhang, N. N. Rao., T. Shiba, A. Kornberg, Inorganic polyphosphate in the social life of Myxococcus xanthus: Motility, development, and predation., Proc. Natl. Acad. Sci. USA 102, 13416-13420 (2005).
  27. T. Shiba, H. Itoh, A. Kameda, Y. Kawazoe, K. Kobayashi, T. Noguchi, Polyphosphate:AMP phosphotransferase as a polyphosphate dependent nucleoside monophosphate kinase in Acinetobacter johnsonii 210A., J. Bacteriol., 187, 1859-1865 (2005).
  28. H. Itoh and T. Shiba, Polyphosphate synthetic activity of polyphosphate:AMP phosphotransferase in Acinetobacter johnsonii 210A., J. Bacteriol. 186, 5178-5181 (2004).
  29. Y. Kawazoe, T. Shiba, R. Nakamura, A. Mizuno, K. Tsutsumi, T. Uematsu, M. Yamaoka, M. Shindoh, T. Kohgo, Induction of calcification in MC3T3-E1 cells by inorganic polyphosphate., J. Dent. Res. 83, 613-618 (2004).
  30. T. Shiba, Y. Takahashi, T. Uematsu, Y. Kawazoe, K. Ooi, K. Nasu, H. Itoh, H. Tanaka, M. Yamaoka, M. Shindoh, T. Kohgo, Effect of Inorganic Polyphosphate on Periodontal Regeneration., Key Engineering Materials, 254-256, 1119-1122 (2004).
  31. T. Shiba, D. Nishimura, Y. Kawazoe, Y. Onodera, K. Tsutsumi, R. Nakamura, M. Ohshiro, Modulation of mitogenic activity of fibroblast growth factors by inorganic polyphosphate., J. Biol. Chem. 278, 26788-26792 (2003).
  32. K. Ishige, T. Hashimoto, T. Shiba, T. Noguchi, Novel method for enzymatic synthesis of CMP-NeuAc., Biosci. Biotechnol. Biochem., 65, 1736-1740 (2001).
  33. A. Kameda, T. Shiba, Y. Kawazoe, Y. Satoh, Y. Ihara, K. Ishige, T. Noguchi, A novel regeneration system using polyphsophate-AMP phosphotransferase and polyphosphate kinase., J. Biosci. Biotechnol. 9, 557-563 (2001).
  34. K, Tsutsumi, M. Munekata, T. Shiba, Involvement of inorganic polyphosphate in expression of SOS genes., Biochim. Biophys. Acta., 1493, 73-81 (2000).
  35. T. Miyake, T. Shiba, A. Kameda, Y. Ihara, M. Munekata, K. Ishige, T. Noguchi, The gene for exopolyphosphatase of Pseudomonas aeruginosa. DNA Research, 6, 103-108 (1999).
  36. T. Noguchi, T. Shiba, Use of Escherichia coli polyphosphate kinase for oligosaccharide synthesis., Biosci. Biotechnol. Biochem., 62, 1594-1596 (1998).
  37. K. Ishige, T. Shiba, T. Noguchi, The polyphosphate kinase gene of Pseudomonas aeruginosa. DNA research, 5, 157-162 (1998).
  38. T. Shiba, K. Tsutsumi, H. Yano, Y. Ihara, A. Kameda, T. Kan, H, Takahashi, M. Munekata, N. N. Rao, A. Kornberg, Inorganic polyphosphate and the induction of rpoS expression., Proc. Natl. Acad. Sci. USA 94, 15146-15152 (1997).
  39. H. Wurst, T. Shiba, A. Kornberg, The gene for a major exopolyphosphatase of Saccharomyces cerevisiae., J. Bacteriol. 177,898-906 (1995).
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